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Fruit Flies, Diabetes, and the Slimming Gene â Offering hope in the future for the treatment of Obesity
For several years, medical scientists at the Life & Medical Sciences Center of the University of Bonn, Germany, have carried out research into the genes of fruit flies.
The common fruit fly is one of the most frequently used organisms used in biological research. It is exceptionally well suited to such studies because of their genetic similarity in so many ways to that of human beings and other mammals.
They are easy to take care of, they mature and breed quickly, they lay many eggs, and have a life span of about 10 days, allowing several generations to be studied in just a few weeks time. A majority of the genes involved in diseases in humans have a similar matching genetic code sequence in fruit flies.
United States also pursues research with fruit flies
Currently also working with fruit flies, as well as the research taking place in Germany, scientists at the University of Maryland in the U.S. are involved in genetic research and on Novemer 2nd of this year, 2009 results of their research was published in “The Proceedings of the National Academy of Sciencesâ€, describing how they altered fruit fly genes to model the failure of insulin production similar to that occurring in Type-1 diabetes. But perhaps that research should be covered separately while here I prefer to concentrate on the Bonn research conclusions that could in the future affect the lives of obese type 2 diabetics, who may continue to produce insulin, compared to the type 1 diabetic whose insulin production by the pancreas fails entirely.
University of Bonn research announcement
The newest announcement of research at the University of Bonn, was on October 15, 2009, through the prestigious molecular biology online journal, EMBO, describes the discovery of yet another fruit fly gene that, if defective, leads to the inability of the fruit fly to metabolize, that is to build, the necessary fat to maintain its health and survival.
The gene is named Schlank by the research team, a German word meaning “slimâ€, now rather obviously being called the slimming gene
The importance of this discovery cannot be overestimated, to have discovered a gene that controls fat metabolism, a gene that when defective prevents the build up of body fat has immense potential consequences in the field of pharmaceuticals that can have an affect on millions of obese people in the world.
It immediately conjures up visions of the development, based on the findings, of the development of a medication that performs in a more limited way, the same thing as the defective fruit fly gene. Long a goal of pharmaceutical companies and those dedicated to the treatment of diabetes.
Human beings and other mammals also carry a gene similar to the Schlank gene, called the Lass gene, a gene that was not known to be involved in the control of fat production. Although it is known that a defective Lass gene is the cause of severe metabolic problems in mammals. Different creatures have different numbers and varieties of the Lass gene, humans have six versions of the gene.
Now with the results of the Bonn team available, Professor Hoch, a member of the Bonn team, is of the opinion that the recent discoveries provide a promising avenue of approach in the search for medications to treat obesity, a major factor in a growing epidemic world-wide of type 2 diabetes.
A recent Gallup survey this year, 2009, offered the conclusion that Americans who are obese are almost three times as likely to be diagnosed as having diabetes as the non-obese population. 26 million Americans already have diabetes and Gallup notes ,that if the current trend continues the number will rise to over 37 million by the end of 2015, a lot more than 10% of the population. And that is for the United States, the story is similar in the U.K., Australia, Europe, and India ,with a population of over one billion people, has the highest number of diabetics of any one country in the world, according to Diabetes UK. India has described itself as the diabetes capital of the world with over 40 million cases.
Obesity, excess body fat that is, has been proven to contribute to diabetes by diminishing the ability of organs of the body to appropriately react to insulin with the end result that blood glucose, derived from the digestion of the foods we eat, stays in the bloodstream, and that is diabetes, pure and simple. The discovery of the newly identified gene responsible the influence of fat in diabetes was also made by the research team from the University of Bonn, announced just last July.
The new discovery of the schlank gene is a great follow-up, a significant finding that holds promise in the fight against obesity and type 2 diabetes.
About the Author
Jim Robinson, the author of this article, is a type 2 diabetic, diagnosed as such about 20 years ago. The experience gained as a patient provides an insight and understanding of the problems that many fellow diabetics face, especially those who have difficulty in controlling their blood glucose levels no matter what efforts they make.
Being himself a diabetic, his diabetes website discusses topics of interest to his fellow diabetics, such as the factors to consider in menu planning at Diabetic Menu Guide where you can also find items on exercise, weight loss, vegetarianism etc.
Now, to cover a wider range of diabetic topics, the Blog-site:
Diabetic Information for Diabetics Like Me
will be launched December 6, 2009.
If you are a diabetic, any of the above are worth a visit, check it out!
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Repashy Superfly 53oz Jar FRUIT FLY CULTURE MEDIA US $8.99
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Fruit Fly Media For Culturing Fruit Flies 1 Gallon Food For Dart Frogs US $22.99
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The Ultimate Fruit Flies Culture Media US $7.49
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5 HUGE 32 oz Cultures Flightless D Hydei Fruit Flies US $21.96
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Premium Flightless D Hydei Fruit Flies 32 oz Culture US $5.49
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5 PACK 32 oz Cultures Wingless Melanogaster Fruit Flies US $21.96
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Catch fruit flies (Drosophila) with vinegar
